The methodological tool of the technology foresight strategy in innovation activity which is based on the new expert estimation principles and software for processing the results of the foresight under the real conditions are proposed. Obviously, this strategy should determine the main development directions of strategically important industries, the prospects of competitiveness products, the sensible use of natural, human, industrial, and scientific resources, and the technological potential of the country, and the strategy should consider the needs of the world market of high technologies and hi-tech products take into account the processes of sustainable development.The real projects were realised on the basis of proposed methodological instrument and created software.